ISPOR—The Professional Society for Health Economics and Outcomes Research (HEOR), and PharmaBoardroom’s content partner, continues to monitor healthcare trends and conduct horizon scanning around the world. The “ISPOR 2024-2025 Top 10 HEOR Trends” marks the fifth publication of the Society’s biennial report, which is based on input from its members and strategic curation from its Health Science Policy Council. To download the full report, visit the ISPOR website.


Real-world evidence (RWE) appears again as the #1 trend in this report. RWE has made the trends list for 4 of 5 reports and has appeared as #1 in the 3 most recent reports. The use of RWE in healthcare decision making is becoming ever more tangible and is increasingly used to augment randomized controlled trials.


Drug pricing is also a recurring theme, appearing as #2 in this report. Drug pricing has appeared in some form in each of the past trends reports. In the United States, the Inflation Reduction Act (IRA) brings a systemic change by introducing drug price negotiations for Medicare. While the IRA directly impacts the United States, it may also impact the rest of the world since US drug profits have historically funded much of the innovation in new drug development.


Artificial intelligence (AI) returns to the trends list as the #3 trend in this report. AI has entered the public conversation in a pronounced way as many people are becoming comfortable with ChatGPT as a tool in their daily lives. AI and machine learning are also employed in HEOR in a variety of ways to gain valuable insights.


A new topic for this report and appearing as the #4 trend—fostering innovation—focuses on the balance of incentivizing the development of innovative, new technologies with affordable pricing. Health equity returns as the #5 trend, having first appeared in the previous report. Accelerated drug approvals returns to the trends list as #6, having first appeared in the inaugural 2018 report. Value measurement appears as #7 in this report and has appeared in some form in the past 3 trends reports. Patient centricity comes in as #8 in this report. Precision medicine returns to the trends list as #9, having previously appeared in the 2019 and 2020 reports. And public health is the #10 trend after first appearing in the 2022-2023 report during the pandemic.


The field of HEOR continues to grow in importance as healthcare systems throughout the globe face increasing pressures. HEOR provides invaluable data to core healthcare stakeholders—including researchers and academicians, assessors and regulators, payers and policy makers, the life sciences industry, healthcare providers, and patients—to help inform and improve healthcare decisions for all. ISPOR’s members will continue their vital work on these and other HEOR-related topics towards fulfilling the Society’s mission to improve healthcare decisions for patients around the world.


The complete 2024-2025 Top 10 HEOR Trends report can be found at