The top COVID-19 Vaccines by revenue in 2021 and sales projections for 2022 based on Airfinity's COVID-19 Vaccine Market Revenue Forecast 2022. Pfizer/BioNTech's vaccine stands to make USD 42.69 billion in 2022, while Moderna's product has projected sales of USD 25.71 billion. Projected USD 3.97 billion sales for Russia's Sputnik V vaccine may be affected by Russia's war in Ukraine and subsequent international sanctions on the country.